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Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir

Academic Article
Publication Date:
2022
abstract:
Coronavirus disease (COVID-19) in patients undergoing hematopoietic stem cell transplantation (HSCT) is a major issue. None of the published papers have reported data on the outcome of HSCT patients with COVID-19 according to the vaccination status and the short course of remdesivir (RDV). Therefore, we present the case of a 22-year-old man with relapsed testicular non-seminomatous germ-cell tumor who was diagnosed with COVID-19 during his first auto-HSCT. Our case report is the first one describing the efficacy of early RDV (and its anti-inflammatory effects that might counterbalance the negative effect of the recombinant human granulocyte-colony stimulating factors -rhG-CSF-) in the context of severe neutropenia following HSCT with the concomitant onset of COVID-19.
Iris type:
1.1 Articolo in rivista
Keywords:
COVID-19; G-CSF; hematopoietic stem cell transplantation (HSCT); neutropenia; remdesivir; vaccine
List of contributors:
Lasagna, Angioletta; Piralla, Antonio; Secondino, Simona; Sacchi, Paolo; Baldanti, Fausto; Bruno, Raffaele; Pedrazzoli, Paolo
Authors of the University:
BALDANTI FAUSTO
BRUNO RAFFAELE
PEDRAZZOLI PAOLO
PIRALLA ANTONIO
Handle:
https://iris.unipv.it/handle/11571/1477267
Published in:
FRONTIERS IN MEDICINE
Journal
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