Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: A comparative analysis of the COVAD surveys
Articolo
Data di Pubblicazione:
2023
Abstract:
Objective: COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys. Methods: The first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups. Results: We analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs - OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs - OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7-10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8-0.97)]. Conclusion: Vaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
autoimmune disease; COVID-19 vaccines; idiopathic inflammatory myopathies; registries; vaccine hesitancy
Elenco autori:
Sen, P.; Naveen, R.; Houshmand, N.; Moghadam Kia, S.; Joshi, M.; Saha, S.; Jagtap, K.; Agarwal, V.; Nune, A.; Nikiphorou, E.; Tan, A. L.; Shinjo, S. K.; Ziade, N.; Velikova, T.; Milchert, M.; Parodis, I.; Gracia-Ramos, A. E.; Cavagna, L.; Kuwana, M.; Knitza, J.; Makol, A.; Patel, A.; Pauling, J. D.; Wincup, C.; Barman, B.; Zamora Tehozol, E. A.; Rojas Serrano, J.; Garcia-De La Torre, I.; Colunga-Pedraza, I. J.; Merayo-Chalico, J.; Chibuzo, O. C.; Katchamart, W.; Akawatcharangura Goo, P.; Shumnalieva, R.; Chen, Y. -M.; Hoff, L. S.; El Kibbi, L.; Halabi, H.; Vaidya, B.; Sazliyana Shaharir, S.; Hasan, A. T. M. T.; Dey, D.; GutiCrossed D SignCopyrightrrez, C. E. T.; Caballero-Uribe, C. V.; Lilleker, J. B.; Salim, B.; Gheita, T.; Chatterjee, T.; Distler, O.; Saavedra, M. A.; Day, J.; Chinoy, H.; Kardes, S.; Andreoli, L.; Lini, D.; Screiber, K.; Vince, M. N.; Singh, Y. P.; Ranjan, R.; Jain, A.; Pandya, S. C.; Pilania, R. K.; Sharma, A.; Manesh Manoj, M.; Gupta, V.; Kavadichanda, C. G.; Patro, P. S.; Ajmani, S.; Phatak, S.; Goswami, R. P.; Chowdhury, A. C.; Mathew, A. J.; Shenoy, P.; Asranna, A.; Bommakanti, K. T.; Shukla, A.; Pande, A. R.; Chandwar, K.; Ghodke, A.; Boro, H.; Fazal, Z. Z.; Cansu, D. U.; Ylldlrlm, R.; Gasparyan, A. Y.; Del Papa, N.; Sambataro, G.; Fabiola, A.; Govoni, M.; Parisi, S.; Bocci, E. B.; Sebastiani, G. D.; Fusaro, E.; Sebastiani, M.; Quartuccio, L.; Franceschini, F.; Sainaghi, P. P.; Orsolini, G.; De Angelis, R.; Danielli, M. G.; Venerito, V.; Grignaschi, S.; Giollo, A.; Alluno, A.; Ioannone, F.; Fornaro, M.; Traboco, L. S.; Wibowo, S. A. K.; Loarce-Martos, J.; Prieto-Gonzalez, S.; Gonzalez, R. A.; Yoshida, A.; Nakashima, R.; Sato, S.; Kimura, N.; Kaneko, Y.; Gono, T.; Tomaras, S.; Proft, F. N.; Holzer, M. -T.; Gromova, M. A.; Aharonov, O.; Griger, Z.; Hmamouchi, I.; El Bouchti, I.; Baba, Z.; Giannini, M.; Maurier, F.; Campagne, J.; Meyer, A.; Langguth, D.; Limaye, V.; Needham, M.; Srivastav, N.; Hudson, M.; Landon-Cardinal, O.; Zuleta, W. G. R.; Arbelaez, A.; Cajas, J.; Silva, J. A. P.; Fonseca, J. E.; Zimba, O.; Bohdana, D.; Ima-Edomwonyi, U.; Dedeke, I.; Airenakho, E.; Madu, N. H.; Yerima, A.; Olaosebikan, H.; Becky, A.; Koussougbo, O. D.; Palalane, E.; So, H.; Ugarte-Gil, M. F.; Chinchay, L.; Bernaola, J. P.; Pimentel, V.; Fathi, H. M.; Mohammed, R. H. A.; Harifi, G.; Fuentes-Silva, Y.; Cabriza, K.; Losanto, J.; Colaman, N.; Cachafeiro-Vilar, A.; Bautista, G. G.; Ho, E. J. G.; Gonzalez, R.; Nunez, L. S.; Cristian Vergara, M.; Baez, J. T.; Alonzo, H.; Pastelin, C. B. S.; Salinas, R. G.; Obiols, A. Q.; Chavez, N.; Ordonez, A. B.; Argueta, S.; Llerena, G. A. R.; Sierra-Zorita, R.; Arrieta, D.; Hidalgo, E. R.; Saenz, R.; Idania Escalante, M.; Morales, R.; Calapaqui, W.; Quezada, I.; Arredondo, G.; Gasparyan, A. Y.; Agarwal, V.; Aggarwal, R.; Gupta, L.
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