The Role of Microbiota in Skin Regeneration

In wound healing, the role of microorganisms is no longer considered just counteracting, but also promoting, although the local application of bacterial products to enhance regeneration has rarely been reported. Various types of immune and non-immune cells contribute to wound healing and the skin microbiota assists innate immunity and influences adaptive immunity. As notoriously thermal spring waters, rich in non-pathogenic bacteria, can boost scar maturation and heal skin lesions, our research group assessed the regenerative properties of a spring water (Comano, TN, Italy) in an experimental both animal and ex vivo human wound model and in vitro human skin fibroblasts. According to our results, the microbial population of thermal (deep) waters might be considered as a potential tool in regenerative medicine and surgery.