Dose estimation in B16 tumour bearing mice for future irradiation in the thermal column of the TRIGA reactor after B/Gd/LDL adduct infusion.
Academic Article
Publication Date:
2011
abstract:
To testtheefficacyofanew 10B-vectorcompound,theB/Gd/LDLadductsynthesisedatTorino
University, in vivo irradiationsofmurinetumoursareinprogressattheTRIGAMarkIIreactorofthe
Pavia University.AlocalisedB16melanomatumourisgeneratedinC57BL/6miceandsubsequently
infused withtheadduct.Duringtheirradiation,themousewillbeputinashieldtoprotectthewhole
body exceptthetumourintheback-neckarea.Tooptimisethetreatmentset-up,MCNPsimulations
were performed.AverysimplifiedmousemodelwasbuiltusingMCNPgeometrycapabilities,aswellas
the geometryoftheshieldmadeof99% 10B enrichedboricacid.Aholeintheshieldisforeseenin
correspondenceoftheback-neckregion.Manyconfigurationsoftheshieldweretestedintermsof
neutronflux,dosedistributionandmeaninducedactivityinthetumourregionandintheradio-
sensitiveorgansofthemouse.Inthefinalset-up,uptofivemicecanbetreatedsimultaneouslyinthe
reactorthermalcolumnandtheneutronfluenceinthetumourregionfor10minofirradiationisof
about 51012 cm2.
Iris type:
1.1 Articolo in rivista
Keywords:
BNCT; animal irradiation; dosimetry calculation
List of contributors:
Protti, Nicoletta; Ballarini, Francesca; Bortolussi, Silva; Stella, Sabrina; Bruschi, Piero; Geninatti, Simonetta; Alberti, Diego; Aime, Silvio; Altieri, Saverio
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