Publication Date:
1986
abstract:
The role of autonomic nervous system in the genesis of reperfusion arrhythmias
is still controversial. Two confounding factors in the
evaluation of the specific role of parasympathetic tone are: the concomitant sympathetic
activation occurring rvhen the vago-sympathetic trunk is stimulated in the dog and the reduction in heart rate with the attendant amelioration in the degree of ischemia induced by vagal stimulation. We evaluated the effect of vagotomy and of vagal stimulation on the incidence of reperfusion arrhythmias using an animal species,
the feline, in which a pure vagal stimulation can be performed. To avoid any effect
on the degree of ischemic damage, vagal stimulation was started only few seconds
before reperfusion. Heart rate was either allowed to decrease or kept constant by ventricular
pacing.
is still controversial. Two confounding factors in the
evaluation of the specific role of parasympathetic tone are: the concomitant sympathetic
activation occurring rvhen the vago-sympathetic trunk is stimulated in the dog and the reduction in heart rate with the attendant amelioration in the degree of ischemia induced by vagal stimulation. We evaluated the effect of vagotomy and of vagal stimulation on the incidence of reperfusion arrhythmias using an animal species,
the feline, in which a pure vagal stimulation can be performed. To avoid any effect
on the degree of ischemic damage, vagal stimulation was started only few seconds
before reperfusion. Heart rate was either allowed to decrease or kept constant by ventricular
pacing.
Iris type:
2.1 Contributo in volume (Capitolo o Saggio)
Keywords:
vagal hyperactivity; Arrhythmia
List of contributors:
Zuanetti, G; DE FERRARI, Gaetano; Priori, SILVIA GIULIANA; Schwartz, Peter
Book title:
NEURAL MECHANISMS AND CARDIOVASCULAR DISEASE