JOURNAL OF MEDICINAL CHEMISTRY

Journal

Identifier:

E092714

ISSN:

0022-2623

Overview

Outputs (77)

1,5-diphenyl pyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.

Academic Article

4-Aminoquinolone Piperidine Amides: Non-Covalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity.

Academic Article

5,6-diphenylpyridazine derivatives as acyl-CoA : cholesterol acyltransferase inhibitors

Academic Article

6-Chloropyridazin-3-yl Derivatives Active as Nicotinic Agents: Synthesis, Binding and Modelling Studies

Academic Article

A 500-MHz proton nuclear magnetic resonance study of μ opioid peptides in a simulated receptor environment

Academic Article

A New Fluorogenic Peptide Determines Proteasome Activity in Single Cells

Academic Article

Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design

Academic Article

BINOL-Amino Acid Conjugates as Triggerable Carriers of DNA-targeted Potent Photocytotoxic Agents

Academic Article

Binding of Monovalent and Bivalent Ligands by Transthyretin Causes Different Short- And Long-Distance Conformational Changes

Academic Article

Binding of Rasagiline-related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis

Academic Article

Biphenyl versus Phenylpyridazine Derivatives: The Role of the Heterocycle in a Series of Acyl-CoA:Cholesterol Acyl Transferase Inhibitors

Academic Article

Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization

Academic Article

Carborane Derivatives Loaded into Liposomes as Efficient Delivery Systems for Boron Neutron Capture Therapy

Academic Article

Cholinergic agents structurally related to furtrethonium II. Synthesis and antimuscarinic activity of a series of N-[5-[(1’-Substituted-acetoxy)methyl]-2-furfury]dialkylamines

Academic Article

Cholinergic agents structurally related to furtrethonium. 2. Synthesis and antimuscarinic activity of a series of N-[5-[(1'-substituted-acetoxy) methyl]-2-furfuryl]dialkylamines.

Academic Article

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs

Academic Article

Conformational Studies of Muscarone Analogs - X-ray-analysis and Molecular Mechanics Calculations

Academic Article

Conformationally Constrained Congeners of 6-aryl-5-methyl-4,5-dihydro-3(2H)-pyridazinones Active On the Cardiovascular system: Conformational Studies By Molecular Mechanics Calculations and 1H NMR Spectroscopy

Academic Article

Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class

Academic Article

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance

Academic Article

Design and Mechanistic Analysis of a Potent Bivalent Inhibitor of Transthyretin Amyloid Fibrillogenesis

Academic Article

Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach

Academic Article

Design, synthesis, and biological evaluation of combretabenzodiazepines: A novel class of anti-tubulin agents

Academic Article

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

Academic Article

Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity

Academic Article

Discovery of Small Peptides Derived from Embryonic Lethal Abnormal Vision Proteins Structure Showing RNA-Stabilizing Properties

Academic Article

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

Academic Article

Down-Regulation of the Androgen Receptor by G-Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide

Academic Article

Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug

Academic Article

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections

Academic Article

Fast Three Dimensional Pharmacophore Virtual Screening of New Potent Non-Steroid Aromatase Inhibitors

Academic Article

G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action

Academic Article

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents

Academic Article

High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.

Academic Article

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents

Academic Article

Identification of Compounds Targeting HuD. Another Brick in the Wall of Neurodegenerative Disease Treatment

Academic Article

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity

Academic Article

In Silico-Guided Discovery and In Vitro Evaluation of Natural Sortase A Inhibitors to Fight Multidrug-Resistant Staphylococcus aureus

Academic Article

Inactivation of Purified Human Recombinant Monoamine Oxidases A and B by Rasagiline and Its Analogues

Academic Article

Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationships.

Academic Article

Molecular modeling and synthesis of inhibitors of Herpes Simplex Virus type 1 uracil-DNA glycosylase

Academic Article

Molecular modelling and synthesis of inhibitors of herpes simplex virus type 1 Uracil-DNA glycosylase

Academic Article

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: Synthesis, activity, and modeling

Academic Article

Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors

Academic Article

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Academic Article

N-[omega-(Tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine are highly potent and selective sigma1 or sigma2 ligands.

Academic Article

Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy

Academic Article

New LsrK Ligands as AI-2 Quorum Sensing Interfering Compounds against Biofilm Formation

Academic Article

New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.

Academic Article

Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton

Academic Article

Novel non-substrate inhibitors of human thymidine phosphorylase: prospect for the control of tumor-dependent angiogenesis

Academic Article

Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis

Academic Article

Novel potent AMPA/kainate receptor antagonists: Synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-aminophenyl)methyl]-4,5-methylenedioxypheny lacetic acid alkyl esters

Academic Article

Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives.

Academic Article

Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine.

Academic Article

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

Academic Article

Shedding X-ray light on the role of magnesium in the activity of M. tuberculosis salicylate synthase (MbtI) for drug design

Academic Article

Small-molecule targeting of heat shock protein 90 chaperone function: Rational identification of a new anticancer lead

Academic Article

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

Academic Article

Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents

Academic Article

Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B

Academic Article

Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).

Academic Article

Structure-acitivity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors

Academic Article

Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs

Academic Article

Structure–Activity Study on Substituted, Core-Extended, and Dyad Naphthalene Diimide G-Quadruplex Ligands Leading to Potent Antitrypanosomal Agents

Academic Article

Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases.

Academic Article

Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists

Academic Article

Synthesis and in vitro anti-Mycobacterium activity of N-alkyl-1,2-dihydro-2-thioxo-3-pyridinecarbothioamides. Preliminary toxicity and pharmacokinetic evaluation

Academic Article

Synthesis and pharmacological investigation of the enantiomers of muscarone and allomuscarone.

Academic Article

Synthesis, Binding and Antiviral Properties of Potent Core-extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-quadruplexes

Academic Article

Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.

Academic Article

Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities

Academic Article

Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands

Academic Article

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration

Academic Article

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship

Academic Article

Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis

Academic Article

Tricyclic Pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6- tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

Academic Article

No Results Found

JOURNAL OF MEDICINAL CHEMISTRY

Overview

Outputs (77)