ID:
510601
Duration (hours):
80
CFU:
9
SSD:
CHIMICA FARMACEUTICA
Year:
2025
Overview
Date/time interval
Primo Semestre (29/09/2025 - 23/01/2026)
Syllabus
Course Objectives
To provide students with the core skills and knowledge on the methodologies used for the rational drug design as well as on the role of Computer Aided Drug Design (CADD) in the drug discovery process.
The students will learn the general principles of drug design and discovery and they will undertake the study of advanced aspects of medicinal chemistry.
The structure-activity relationship and the mechanism of action of agents used to prevent or treat infectious diseases as well as anticancer drugs. The students will acquire knowledge in stereochemical features that affect drug biological activity and techniques which aid the medicinal chemist. Examples of these will include the use of quantitative structure activity relationships (QSAR), and computer-aided drug design.
The students will learn the general principles of drug design and discovery and they will undertake the study of advanced aspects of medicinal chemistry.
The structure-activity relationship and the mechanism of action of agents used to prevent or treat infectious diseases as well as anticancer drugs. The students will acquire knowledge in stereochemical features that affect drug biological activity and techniques which aid the medicinal chemist. Examples of these will include the use of quantitative structure activity relationships (QSAR), and computer-aided drug design.
Course Prerequisites
Basic knowledge of organic chemistry, microbiology, pharmacology and Medicinal Chemistry is required.
Teaching Methods
Frontal lessons (ppt presentations),
available on kiro-platform. A font recommended for DSA students is used for presentations. Teaching methods used in the course include lectures, problem-based learning groups, independent study. Various problem assignments are given to the students during the course to illustrate the course content. Discussion of the lecture topics during class is ecouraged. Lectures will be held by industrial experts, working in medicinal chemistry field.
available on kiro-platform. A font recommended for DSA students is used for presentations. Teaching methods used in the course include lectures, problem-based learning groups, independent study. Various problem assignments are given to the students during the course to illustrate the course content. Discussion of the lecture topics during class is ecouraged. Lectures will be held by industrial experts, working in medicinal chemistry field.
Assessment Methods
Student performance can be assessed at the end of the lectures or at one of the official exams. There will be two in-itinere tests, one written intermediate test lasting 90 minutes, with short-answer and open-ended questions.
The short-answer questions (varying in number from 4 to 6, depending on the difficulty with a score ranging from 3 to 4 points) can be of different types: (1) asked to report or (2) to recognise the structure of a class of drugs treated during the course and to briefly describe their mechanism of action, (3) to report the general structure of a class of drugs, structure-activity relationships and therapeutic uses. Open questions and an oral exam upon completion of the course. The open questions (2 or 3, which will be awarded a mark ranging from 6 to 8 points depending on the difficulty) involve a full discussion of a class of drugs including the rationale behind their discovery and specific use. The oral test consists of the presentation and discussion of an in-depth report on a specific topic chosen from the programme, and a test of the student's general knowledge of the other topics presented in the course. The aim is to test the student's level of understanding as well as his or her ability to synthesise, explain clearly and communicate. The aim is to stimulate the student towards a professional approach to unfamiliar problems/topics. Conditions for passing the course: passing both the in itinere tests and the final test, which consists of a written test lasting 90 minutes and an oral test. The short-answer questions (varying in number from 4 to 6, depending on the difficulty with a score ranging from 3 to 4 points) can be of different types: (1) required to report or (2) to recognise the structure of a class of drugs treated during the course and to briefly describe their mechanism of action, (3) to report the general structure of a class of drugs, structure-activity relationships and therapeutic uses. Open questions and an oral exam upon completion of the course. The open questions (2 or 3, which will be awarded a mark ranging from 6 to 8 points depending on the difficulty) involve a complete discussion of a class of drugs including the rationale behind their discovery and their specific use. The oral test consists of verifying knowledge of the topics presented in the course, in particular those relating to the drug design, or the presentation and discussion of an in-depth report on a specific topic treated during the course. The test is graded in thirtieths (0-30). In the case of in itinere tests, the final mark of the test corresponds to the average of the marks. The results of the written test will be announced via the essetre platform. The written exams are available to the students.
The examination procedures will be further clarified during the course. For DSA students, learning assessment will be carried out in accordance with the SAISD centre statement.
The short-answer questions (varying in number from 4 to 6, depending on the difficulty with a score ranging from 3 to 4 points) can be of different types: (1) asked to report or (2) to recognise the structure of a class of drugs treated during the course and to briefly describe their mechanism of action, (3) to report the general structure of a class of drugs, structure-activity relationships and therapeutic uses. Open questions and an oral exam upon completion of the course. The open questions (2 or 3, which will be awarded a mark ranging from 6 to 8 points depending on the difficulty) involve a full discussion of a class of drugs including the rationale behind their discovery and specific use. The oral test consists of the presentation and discussion of an in-depth report on a specific topic chosen from the programme, and a test of the student's general knowledge of the other topics presented in the course. The aim is to test the student's level of understanding as well as his or her ability to synthesise, explain clearly and communicate. The aim is to stimulate the student towards a professional approach to unfamiliar problems/topics. Conditions for passing the course: passing both the in itinere tests and the final test, which consists of a written test lasting 90 minutes and an oral test. The short-answer questions (varying in number from 4 to 6, depending on the difficulty with a score ranging from 3 to 4 points) can be of different types: (1) required to report or (2) to recognise the structure of a class of drugs treated during the course and to briefly describe their mechanism of action, (3) to report the general structure of a class of drugs, structure-activity relationships and therapeutic uses. Open questions and an oral exam upon completion of the course. The open questions (2 or 3, which will be awarded a mark ranging from 6 to 8 points depending on the difficulty) involve a complete discussion of a class of drugs including the rationale behind their discovery and their specific use. The oral test consists of verifying knowledge of the topics presented in the course, in particular those relating to the drug design, or the presentation and discussion of an in-depth report on a specific topic treated during the course. The test is graded in thirtieths (0-30). In the case of in itinere tests, the final mark of the test corresponds to the average of the marks. The results of the written test will be announced via the essetre platform. The written exams are available to the students.
The examination procedures will be further clarified during the course. For DSA students, learning assessment will be carried out in accordance with the SAISD centre statement.
Texts
PPT presentations (kiro platform, https://elearning.unipv.it/ )-
Students who cannot attend are required to contact the teacher, who will provide additional material.
Reviews on hot topics.
Roche, Zito, Lemke & Williams “Foye’s Principi di Chimica Farmaceutica”,
Piccin. Settima Ed Italiana, 2021
Patrick GL “Introduzione alla Chimica farmaceutica” Edises. Seconda Ed
Italiana, 2010 Wilson and Gisvold’s Textbook of Organic, Medicinal and Pharmaceutical Chemistry, 12th edition, di J. M. Beale, Jr, e J.
H. Block. Casa Editrice Ambrosiana 2014
“Introduzione alla Chimica Farmaceutica” Graham L. Patrick EdiSES, Napoli.
Students who cannot attend are required to contact the teacher, who will provide additional material.
Reviews on hot topics.
Roche, Zito, Lemke & Williams “Foye’s Principi di Chimica Farmaceutica”,
Piccin. Settima Ed Italiana, 2021
Patrick GL “Introduzione alla Chimica farmaceutica” Edises. Seconda Ed
Italiana, 2010 Wilson and Gisvold’s Textbook of Organic, Medicinal and Pharmaceutical Chemistry, 12th edition, di J. M. Beale, Jr, e J.
H. Block. Casa Editrice Ambrosiana 2014
“Introduzione alla Chimica Farmaceutica” Graham L. Patrick EdiSES, Napoli.
Contents
The process of drug discovery and development from the identification of novel drug targets to the introduction of new
drugs into clinical practice. The basic principles of how new drugs are discovered with emphasis on lead identification
and optimization, as well as on structure-based drug design methods will be presented. The drug discovery from plants
will also be considered. Principles of antimicrobial chemotherapy, the study of infectious disease therapeutics topics (anti-infective
drugs, including agents active against bacterial, malarial, and tuberculosis infections). In detail, chemical and
biologic properties of agents used to prevent or treat infectious diseases, including diagnostic, prophylactic, and
therapeutic uses of immunizing biologicals and therapeutic applications of antibiotics, antifungals, and antivirals will be
examined. Specific classes of agents that are covered include anti-cancer drugs. Case studies of selected modern drugs
will be presented and discussed.
drugs into clinical practice. The basic principles of how new drugs are discovered with emphasis on lead identification
and optimization, as well as on structure-based drug design methods will be presented. The drug discovery from plants
will also be considered. Principles of antimicrobial chemotherapy, the study of infectious disease therapeutics topics (anti-infective
drugs, including agents active against bacterial, malarial, and tuberculosis infections). In detail, chemical and
biologic properties of agents used to prevent or treat infectious diseases, including diagnostic, prophylactic, and
therapeutic uses of immunizing biologicals and therapeutic applications of antibiotics, antifungals, and antivirals will be
examined. Specific classes of agents that are covered include anti-cancer drugs. Case studies of selected modern drugs
will be presented and discussed.
Course Language
Italian
More information
Tutorial is part of the teaching activity and includes classroom tutorial to guide the team-working activities and to
address the "in itinere" tests as well as the final examination. Tutorial activities
could be performed on-line
address the "in itinere" tests as well as the final examination. Tutorial activities
could be performed on-line
Degrees
Degrees
MEDICINAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY
Single-cycle Master’s Degree
5 years
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People
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