The course aims to provide the student with knowledge on the physicochemical properties of the drugs and excipients implicated in both discovery and final dosage form development and how such properties, as well as the dosage forms and routes of administration, affect the rate and extent of drug absorption.
Metodi didattici
Class lectures, supplemented by multimedia material selected by the teaching. Students will be personally involved through seminars they hold on topics related to the course. For students with specific needs, who cannot attend in person the teaching activities and who have applied for Inclusive Teaching Methods, the professor will provide teaching material suitable for independent study. If requested, self-learning can be supported by supplementary teaching activities and dedicated meetings, also online, with flexible hours depending on the needs.
Verifica Apprendimento
Learning assessment is performed in the form of written test consisting of open questions. The weight of the individual questions in the overall assessment is variable and is detailed in each test. The duration of the test is 2 hours. The results of the tests will be made known through esse3.
Testi
M.E. Aulton, Pharmaceutics, The science of dosage form design. Ed. Churchill-Livingstone A.T. Florence and D. Attwood Physicochemical Principles of Pharmacy. Ed. Macmillan A. Martin, Physical Pharmacy, Ed. Lea & Febiger; Wells, Pharmaceutical Preformulation, Ed. Horwood J.I. Wells, Pharmaceutical Preformulation, Ed. Horwood
Contenuti
Introduction to biopharmaceutics. Physical properties: Polymorphsm. Amorphism. Crystallinity. Particle size, shape and surface area. Aqueous solubility as a function of pH. Dissolution rate. Partition coefficient octanol/water. Chemical properties: Stability in solution and in solid state. Expiration date. Basic principles of rheology.
Lingua Insegnamento
INGLESE
Altre informazioni
All educational material is provided via the kiro platform.
