Students will learn how to solve problems of poor solubility for small molecules through formulative strategies involving in particular nanoformulation. They will be aware of the relevance of excipient properties and characterization for the pharmaceutical development.
Metodi didattici
Class lectures. Practical laboratories requiring final reports. Class exercises about topics covered in the course. To strengthen inclusion of students with specific needs, who cannot attend teaching activities in person and who have applied for Inclusive Teaching Modality, adequate teaching material will be available for fruitful independent study, and if requested, self-learning can be supported by dedicated meetings, including online, with time flexibility depending on needs.
Verifica Apprendimento
1) written essay questions, to evaluate the ability to recognize and analyze the critical aspects of pharmaceutical development steps. 2) short questions 3) exercises about topics covered in the course
Testi
Martin A., Physical Pharmacy, Ed. Lea & Febiger; Wells, Pharmaceutical Preformulation, Ed. Horwood; Florence-Atwood, Physico-chemical Principles of Pharmacy, Ed. Macmillan M.E. Aulton, Pharmaceutics, The science of dosage form design. Ed. Churchill-Livingstone
Contenuti
Formulation strategies for poorly soluble drugs and nanosystems based on lipid ingredients. Methods to improve solubility of small molecules. Polymeric and lipidic excipient properties and characterization. Drug-excipient compatibility studies.