ID:
510609
Duration (hours):
72
CFU:
9
SSD:
CHIMICA FISICA
Year:
2025
Overview
Date/time interval
Primo Semestre (29/09/2025 - 23/01/2026)
Syllabus
Course Objectives
At the end of the course the student must:
- know and be able to apply the principles of thermodynamics to real situations drawn from the world of pharmaceutical chemistry and pharmacology, biology and medicine;
- know how to read and understand the description sheet of any chemical substance (state of aggregation, melting and boiling points, enthalpies and characteristic transition free energies);
- know how to make calculations related to chemical and chemical-physical equilibrium, predicting the state of aggregation of substances and drawing the relative phase diagram (solid - liquid, liquid - vapour, with one or two components);
- know how to make calculations related to chemical kinetics and enzymatic kinetics.
- know and be able to apply the principles of thermodynamics to real situations drawn from the world of pharmaceutical chemistry and pharmacology, biology and medicine;
- know how to read and understand the description sheet of any chemical substance (state of aggregation, melting and boiling points, enthalpies and characteristic transition free energies);
- know how to make calculations related to chemical and chemical-physical equilibrium, predicting the state of aggregation of substances and drawing the relative phase diagram (solid - liquid, liquid - vapour, with one or two components);
- know how to make calculations related to chemical kinetics and enzymatic kinetics.
Course Prerequisites
Chemistry: states of aggregation of matter; chemical properties and physical properties; fundamental laws of chemistry; fundamental laws of ideal gases; atoms and molecules, atomic weight and molecular weight; atomic structure; fundamental subatomic particles; electronic configuration of the elements and periodic table; periodic properties; The chemical bond: atomic orbitals and molecular orbitals. Chemical nomenclature: acids, bases, salts. Basic principles of organic chemistry and nomenclature of alkanes, alkenes, alcohols.
Mathematical analysis: concepts of: function (also with several variables), limit, derivative, integral. Calculation: powers of 10, equivalences.
Physics: measurement of physical quantities and measurement units, conversion factors between quantities, fundamental principles and equations of mechanics, principle of conservation of energy.
Mathematical analysis: concepts of: function (also with several variables), limit, derivative, integral. Calculation: powers of 10, equivalences.
Physics: measurement of physical quantities and measurement units, conversion factors between quantities, fundamental principles and equations of mechanics, principle of conservation of energy.
Teaching Methods
Teaching is based on both lectures and guided problems solving in the classroom. For carrying out the frontal lessons, Power Point presentations are used, made available to the students in the section dedicated to teaching on the moodle KIRO platform. Guided problem solving is performed using the whiteboard and/or a graphics tablet. Each single step is illustrated to the students and discussed with them to verify their understanding of the related covered topics . Similar exercises are uploaded to the Kilo platform in pdf format for students to practice. The solutions are provided on separate files. The face-to-face tutoring serves as a support to this activity. For students with specific needs, who cannot attend teaching activities in person and who have applied for Inclusive Teaching Modality, adequate teaching material will be available for fruitful independent study. If requested, self-learning can be supported by tutoring or supplementary teaching activities, and by dedicated meetings, including online ones, with time flexibility depending on needs.
Assessment Methods
The learning verification will take place individually in a mixed form: the first part will be conducted orally and will consist of open questions relating to the entire program of the course, with particular attention to the principles of thermodynamics, the concept of chemical equilibrium and the kinetic laws; the second part will be conducted as written part and will consist in the resolution of problems taken from the world of pharmaceutical chemistry and biology relating to the application of the thermodynamic and kinetic laws studied during the course and in the reproduction of one or more phase diagrams with the relative thermodynamic description. The oral part lasts 30 minutes, the written part 45 minutes. The use of the periodic table and the calculator is permitted. The evaluation of the test is carried out in thirtieths. Appropriate examination methods are provided for students belonging to the categories of Specific Learning Disorders (SLD) and Special Educational Needs (SEN).
Texts
The slides provided in power point by the teacher constitute a solid basis for the preparation of the course, together with the exercises made available in pdf format.
The recommended texts are:
1) Atkins - De Paula - Keeler, Chimica fisica, 2020, Zanichelli, Edizione 2020; Edizione 2022 in inglese + Ebook su Zanichelli/CEA LockLizard.
2) Atkins - De Paula, Chimica fisica biologica, Volume 1, 2008, Zanichelli, Edizione 2008; Edizione 2011 in inglese.
3) Chang, Chimica fisica, Zanichelli, 2003, Edizione 2003.
The recommended texts are:
1) Atkins - De Paula - Keeler, Chimica fisica, 2020, Zanichelli, Edizione 2020; Edizione 2022 in inglese + Ebook su Zanichelli/CEA LockLizard.
2) Atkins - De Paula, Chimica fisica biologica, Volume 1, 2008, Zanichelli, Edizione 2008; Edizione 2011 in inglese.
3) Chang, Chimica fisica, Zanichelli, 2003, Edizione 2003.
Contents
The course provides the fundamental physics-chemical tools for understanding the subsequent courses of pharmaceutical analysis and technology and for carrying out thermodynamic and kinetic calculations for the scale up of reactions of pharmaceutical interest. Main topics covered. The principles of thermodynamics. The internal energy, enthalpy and entropy functions: meaning and importance in the chemical, biological and pharmaceutical fields. Chemical and biological fuels. The energetic problem. Carnot's machine: theoretical examples and practical applications. The free energy function. The chemical equilibrium. The chemical potential. Laws of Dalton, Raoult and Henry. The phase rule. Polymorphism. Solid-liquid equilibrium and liquid-vapour equilibrium. Distillation and fractional distillation. Colligative properties: phenomenology and empirical laws. Chemical kinetics. Arrhenius law. Chemical and biological catalysts. All topics are accompanied by numerical/applicative examples in the pharmaceutical and biological fields.
Course Language
Italian
More information
Teacher office hours: Tuesday and Thursday from 10 to 12. Frontal tutoring organized once a week from the beginning of the course.
Degrees
Degrees
MEDICINAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY
Single-cycle Master’s Degree
5 years
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People
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