ID:
510606
Duration (hours):
48
CFU:
6
SSD:
CHIMICA ORGANICA
Year:
2025
Overview
Date/time interval
Primo Semestre (29/09/2025 - 23/01/2026)
Syllabus
Course Objectives
At the end of the course the student will have in-depth study the reactivity of some classes of organic compounds have already been introduced in the course of Organic Chemistry 1, and he will have acquired a general knowledge of the nomenclature, preparation and reactivity of the most common heterocyclic compounds. This knowledge is a prerequisite for the study of Medicinal Chemistry. He will also acquire the basic knowledge on the chemistry of natural organic substances, in order to prepare the biochemistry studies.
Course Prerequisites
To attend this course the basic knowledge provided by the courses of General and Inorganic Chemistry and Organic Chemistry 1 of the first year of course are required.
Teaching Methods
Lectures carried out on the blackboard and by means of presentations (PowerPoint) projected onto the screen. Exercises will also be proposed and solved by the teacher in preparation for the written test.
Assessment Methods
he final written exam is divided into two parts: reactivity (Part A) and spectroscopic methods (Part B). The overall mark will derive from the straight combination of the marks obtained taking into account the breadth of the two programs. As regards Part A, the vote will derive from the resolution of a paper consisting of problems and questions with single or multiple answers.
It will not be a notional examination but of reasoning, therefore in the examination the notes and / or the nomenclature tables of heterocyclic compounds can be used.
It will not be a notional examination but of reasoning, therefore in the examination the notes and / or the nomenclature tables of heterocyclic compounds can be used.
Texts
W. H. Brown, B. L. Iverson, E. V. Anslyn, C. S. Foote; Chimica Organica; Edises V ed.
G. Broggini e G. Zecchi; Chimica dei composti eterociclici; Zanichelli.
G. M. Loudon; Organic Chemistry; Oxford Univ. Press.
J. Clayden, N. Greeves, S. Warren; Chimica Organica; Piccin.
G. Broggini e G. Zecchi; Chimica dei composti eterociclici; Zanichelli.
G. M. Loudon; Organic Chemistry; Oxford Univ. Press.
J. Clayden, N. Greeves, S. Warren; Chimica Organica; Piccin.
Contents
Reactivity (Part A): The first part of the course deals with a review and in-depth analysis of organic stereochemistry: CIP rules, stereocenters, elements of stereogenicity and topicality of faces, atoms and groups. Kinetic and thermodynamic control in the formation of enolate. Elements of asymmetric synthesis, kinetic resolutions and dynamic kinetics. Chemistry of enols and enolates, with particular reference to the stereochemical course, transition states of Zimmerman-Traxler. Aminoacids: structures and properties; isoelectric point. Elements of organocatalysis.
The central part of the course will be dedicated to the study of heterocyclic compounds. After the exam
of the nomenclature, the concept of aromaticity referred to heterocyclic nuclei will be re-discussed and the
essential characteristics that differentiate electron-rich and electron-poor nuclei. The systematic study of the
main methods of preparation and general reactivity of classes of heterocyclic compounds, emphasizing similarities and
differences with the aromatic compounds studied in the organic course 1. Outline of reductions and oxidations in organic chemistry: hydrogenations in the hetero- and homogeneous phase.. Most common oxidants, PCC, Dess-Martin, TPAP, and Swern.
The central part of the course will be dedicated to the study of heterocyclic compounds. After the exam
of the nomenclature, the concept of aromaticity referred to heterocyclic nuclei will be re-discussed and the
essential characteristics that differentiate electron-rich and electron-poor nuclei. The systematic study of the
main methods of preparation and general reactivity of classes of heterocyclic compounds, emphasizing similarities and
differences with the aromatic compounds studied in the organic course 1. Outline of reductions and oxidations in organic chemistry: hydrogenations in the hetero- and homogeneous phase.. Most common oxidants, PCC, Dess-Martin, TPAP, and Swern.
Course Language
Italian
More information
Registration for the exam will take place on S3 platform in order to be aware of the number of students and the correct preparation for the Organic Chemistry I exam
Degrees
Degrees
MEDICINAL CHEMISTRY AND PHARMACEUTICAL TECHNOLOGY
Single-cycle Master’s Degree
5 years
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People
People
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