Knowledge of the molecular mechanisms through which microorganisms and viruses affect human health. To understand the different types of vaccines and their role in preventing infectious diseases. Knowledge of the scientific language to properly describe microbial pathogenesis.
Course Prerequisites
Basic knowledge of microbiology, in particular cell structure, microorganism classification, and microbiology techniques; genetics, in particular gene regulation and operon structure; biochemistry, protein structure and function, enzymatic assays.
Teaching Methods
Lectures with discussion with students. Power Point presentations are used for lectures, made available to students in the section dedicated to teaching on the KIRO platform, following the University of Pavia's instructions.
Assessment Methods
Two hours written exam with open questions.
Evaluation expressed out of thirty. During the lessons, numerous examples of exam questions are given.
Texts
Slides plus articles and reviews. "Bacterial pathogenesis": a molecular approach. By Wilson et al. ASM Press.
Contents
Host-Pathogen interaction. Non-specific and specific defenses. Microbial pathogenesis. Mechanisms of bacterial adhesion-invasion. Evasion of host defenses and damage to host cell. Endotoxins and exotoxins. Quorum sensing, biofilm and persistence. Bacterial secretion systems. Multi-drug resistant bacteria and efflux pumps. New antibacterial molecules and drug development. Phage therapy. Vaccines: classic and modern approaches. Animal viruses: viruses responsible for hepatitis, influenza viruses, Coronavirus. Iron uptake. Neglected tropical diseases.
Course Language
English
More information
For the categories of students identified by Senato Accademico in the session of 23 March 2023, the inclusive methods, among those indicated, will be provided and established ad hoc for each student who should need them.
