ID:
510600
Duration (hours):
72
CFU:
9
SSD:
CHIMICA FARMACEUTICA
Year:
2025
Overview
Date/time interval
Primo Semestre (29/09/2025 - 23/01/2026)
Syllabus
Course Objectives
The aim of this course is to provide a suitable information concerning the role and structural properties of drugs important for their biological activity.
The student will be able to correlate chemical characteristics of active molecules to the adsorption, distribution, metabolism, excretion and toxicity. The molecular modifications of lead compounds can be discussed together with the strategies for the drug discovery.
At the end of the course, the student will know the main classes of drugs that interact with neurotransmitter receptors, intracellular receptors, enzymes and ion channels, and, for each class of drugs, the most representative components in use, their chemical-physical and biological properties and their structure-activity relationships.
The student will be able to correlate chemical characteristics of active molecules to the adsorption, distribution, metabolism, excretion and toxicity. The molecular modifications of lead compounds can be discussed together with the strategies for the drug discovery.
At the end of the course, the student will know the main classes of drugs that interact with neurotransmitter receptors, intracellular receptors, enzymes and ion channels, and, for each class of drugs, the most representative components in use, their chemical-physical and biological properties and their structure-activity relationships.
Course Prerequisites
Organic chemistry exam approved. It’s recommended also the exam of biochemistry.
Teaching Methods
Frontal classes performed with informatic support (Slides).
For students with specific needs, who cannot attend educational activities in person and have applied for Inclusive Teaching Methods, appropriate teaching materials will be available for effective self-study. If requested, self-learning can be supported by tutoring or supplementary teaching activities, and dedicated meetings, including online, with flexible scheduling depending on needs.
For students with specific needs, who cannot attend educational activities in person and have applied for Inclusive Teaching Methods, appropriate teaching materials will be available for effective self-study. If requested, self-learning can be supported by tutoring or supplementary teaching activities, and dedicated meetings, including online, with flexible scheduling depending on needs.
Assessment Methods
The student must demonstrate to have acquired what is foreseen by the educational objectives.
In particular, the student must demonstrate that he/she has acquired and understood:
a) the basic concepts of Medicinal Chemistry and the fundamental elements of drug design;
b) the notions provided on the chemical, chemical-physical, structural properties and on the mechanism of action of the drugs belonging to the therapeutic classes considered.
The exam includes a written test at the end of the course relating to Parts A, B and C with multiple choice questions to verify the ability of the student to answer specific questions relating to the topics covered during the lessons and possibly to recognize the structure of the drugs covered.
Conditions for approving the course: sufficiency in written tests Parts A, B and C by means of a computer-based test for admission to the subsequent oral examination.
In particular, the student must demonstrate that he/she has acquired and understood:
a) the basic concepts of Medicinal Chemistry and the fundamental elements of drug design;
b) the notions provided on the chemical, chemical-physical, structural properties and on the mechanism of action of the drugs belonging to the therapeutic classes considered.
The exam includes a written test at the end of the course relating to Parts A, B and C with multiple choice questions to verify the ability of the student to answer specific questions relating to the topics covered during the lessons and possibly to recognize the structure of the drugs covered.
Conditions for approving the course: sufficiency in written tests Parts A, B and C by means of a computer-based test for admission to the subsequent oral examination.
Texts
All material used by the teacher during the lectures will be provided in the Kiro web site
Lemke & Williams “Foye’s Principi di Chimica Farmaceutica”, Piccin.
Patrick GL “Introduzione alla Chimica farmaceutica” Edises.
Lemke & Williams “Foye’s Principi di Chimica Farmaceutica”, Piccin.
Patrick GL “Introduzione alla Chimica farmaceutica” Edises.
Contents
Part A: General medicinal chemistry
Design of new drugs and structure activity relationship. Mechanisms of action of drugs. Chemical, physical and biopharmaceutical properties of drugs and pharmacokinetic. Metabolism of drugs.
Part B. Drugs of peripheral organs and systems.
Drugs active on peripheral nervous system. Drugs for respiratory system. Drugs for gastro-enteric system. Drugs for cardio-circulatory system.
Part C. Drugs for pain treatment and active on the central nervous system.
FANS and drug used for the treatment of migraine.
Drugs for the treatment of pain: local anaesthetic and opioids.
Psychiatric drugs and drugs of abuse
Neurological drugs: anti-spastic, anti-Parkinson and drugs used in the treatment of Alzheimer desease
Design of new drugs and structure activity relationship. Mechanisms of action of drugs. Chemical, physical and biopharmaceutical properties of drugs and pharmacokinetic. Metabolism of drugs.
Part B. Drugs of peripheral organs and systems.
Drugs active on peripheral nervous system. Drugs for respiratory system. Drugs for gastro-enteric system. Drugs for cardio-circulatory system.
Part C. Drugs for pain treatment and active on the central nervous system.
FANS and drug used for the treatment of migraine.
Drugs for the treatment of pain: local anaesthetic and opioids.
Psychiatric drugs and drugs of abuse
Neurological drugs: anti-spastic, anti-Parkinson and drugs used in the treatment of Alzheimer desease
Course Language
Italian
More information
Slides used during lectures can be downloaded from the website Kiro. Registration to the midterm exam is mandatory and must be done by signing up the form in Kiro by the reported deadline. Communications/notices to the students will be uploaded in Kiro, too.
Degrees
Degrees
PHARMACY
Single-cycle Master’s Degree
5 years
No Results Found