ID:
510609
Duration (hours):
48
CFU:
6
SSD:
CHIMICA FISICA
Year:
2025
Overview
Date/time interval
Primo Semestre (29/09/2025 - 23/01/2026)
Syllabus
Course Objectives
The aim of the course is to provide the student with the conceptual foundations and the fundamental elements necessary to deal with pharmaceutical problems through physico-chemical method. Thermodynamics and calorimetric skills useful for the study of phase equilibria and solid state of drugs, knowledge of chemical kinetics applied to the determination of the expiration date of drugs, knowledge of rheology and surface properties useful for the preparation of liquid and semi-solid pharmaceutical dosage forms will be provided.
Course Prerequisites
Knowledge of mathematics, analytical geometry, trigonometry and elements of statistics: powers, logarithms, exponentials, logarithmic and exponential equations, sine, cosine and tangent functions, derivative of a function and rules of derivation, integrals and integral calculus, equation of a straight line, linear regression and correlation.
Basic physics knowledge provided by secondary school.
Knowledge of general and inorganic chemistry: concept of mole, molar mass, molarity, molar fractions, gas laws and equation of state of perfect gases, solubility, chemical bonds.
Basic physics knowledge provided by secondary school.
Knowledge of general and inorganic chemistry: concept of mole, molar mass, molarity, molar fractions, gas laws and equation of state of perfect gases, solubility, chemical bonds.
Teaching Methods
Frontal lessons held with the aid of PowerPoint presentations (also available on the Kiro platform) projected on the screen. The lessons include in-depth explanations and explanations on the blackboard that allow the student to follow the various steps necessary to derive the equations and deal with the construction and discussion of graphs. During the lessons the active participation of the student is strongly encouraged. Working groups are also encouraged which provide for the study of particular topics, the analysis of case studies and of scientific articles relating to the topics covered and subsequent presentations/discussions in which students take an active part.
For students with specific needs, who cannot attend teaching activities in person and who have applied for Inclusive Teaching Modality, adequate teaching material will be available for fruitful independent study. If requested, self-learning can be supported by tutoring or supplementary teaching activities, and by dedicated meetings, including online, with time flexibility depending on needs.
For students with specific needs, who cannot attend teaching activities in person and who have applied for Inclusive Teaching Modality, adequate teaching material will be available for fruitful independent study. If requested, self-learning can be supported by tutoring or supplementary teaching activities, and by dedicated meetings, including online, with time flexibility depending on needs.
Assessment Methods
A final written test at the end of the course or a written test in one of the examination session. In both cases the written test consists of five open-ended questions with the aim of assessing the quantity and quality of learning as well as the ability to identify the core object of the question and know how to discuss it in an understandable, relevant and comprehensive way. The use of appropriate scientific language will also be assessed. The available tine is 75 minutes.
There are no ongoing assessments.
Appropriate examination methods are foreseen for students who fall into the categories foreseen for Specific Learning Disorders (SLD) and Special Educational Needs (SEN)
There are no ongoing assessments.
Appropriate examination methods are foreseen for students who fall into the categories foreseen for Specific Learning Disorders (SLD) and Special Educational Needs (SEN)
Texts
P. Atkins, J. de Paula, J. Keeler, “Chimica Fisica”, Zanichelli.
P. Atkins, J. de Paula, "Elementi di Chimica Fisica", Zanichelli.
A. Martin, “Physical Pharmacy”, Lea & Febiger
P. Atkins, J. de Paula, "Elementi di Chimica Fisica", Zanichelli.
A. Martin, “Physical Pharmacy”, Lea & Febiger
Contents
The principles and the state functions of thermodynamic:
enthalpy, entropy, free energy.
Operating principle of instant hot and cold packs and thermal patches on sale in pharmacies. The solid state and the thermodynamic aspects of the crystalline polymorphism of drugs. Phase equilibria, phase diagrams of one-component and two-component systems. Colligative properties. Physico-chemical method for determining the compatibility between the components of a pharmaceutical formulation. Chemical kinetics: determination of the reaction order, the dependence of the reaction rate on the temperature Determination of the shelf life of pharmaceutical products and of the conditions necessary for its conservation. Rheological properties of materials: Newtonian and non-Newtonian systems. Surface phenomena. Surface tension. Wettability of solids.
enthalpy, entropy, free energy.
Operating principle of instant hot and cold packs and thermal patches on sale in pharmacies. The solid state and the thermodynamic aspects of the crystalline polymorphism of drugs. Phase equilibria, phase diagrams of one-component and two-component systems. Colligative properties. Physico-chemical method for determining the compatibility between the components of a pharmaceutical formulation. Chemical kinetics: determination of the reaction order, the dependence of the reaction rate on the temperature Determination of the shelf life of pharmaceutical products and of the conditions necessary for its conservation. Rheological properties of materials: Newtonian and non-Newtonian systems. Surface phenomena. Surface tension. Wettability of solids.
Course Language
Italian
More information
The teacher is available to meet the student for clarifications by making an appointment via email.
Teacher's email address:
giovanna.bruni@unipv.it
Teacher's email address:
giovanna.bruni@unipv.it
Degrees
Degrees
PHARMACY
Single-cycle Master’s Degree
5 years
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People
People
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