The Sport Pharmacology course is aimed at acquiring the fundamental principles of the biological effects of drugs from the pharmacodynamics, pharmacokinetics, pharmacometabolic and toxicological aspects. The main pharmacological classes used for therapeutic or doping purposes in sports will also be illustrated.
Course Prerequisites
Have basic notions acquired during the courses of Chemistry and Biochemistry of Sport, essential for understanding some topics covered in the Sport Pharmacology course.
Teaching Methods
Lectures carried out through presentations (Power Point) projected on the screen and possible further information using the blackboard.
Assessment Methods
Written examination consisting of 30 multiple choice questions based on didactic material covered in the course, regardless of whether the examination is carried out on paper or electronically.
N.B.: To pass the exam, it is necessary to achieve a passing grade in both parts.
Texts
David R. Mottram, Neil Chester. Drugs in Sport. Routledge; 8h ed. 2022. ISBN-13: 9780367560294
Anna Maria Di Giulio, Alfredo Gorio, e al. Farmacologia generale e speciale. Per le lauree sanitarie. Piccin-Nuova Libraria; 2° ed. ISBN-10 : 8829929425
Prof. Laura Giuseppina Di Pasqua: General principles, drug definition; preclinical and clinical experimentation in pharmacology. Basic principles of pharmacokinetics. Routes of administration and absorption of drugs. Distribution and biotransport processes. Drug metabolism. Induction and inhibition of drug metabolising enzymes. Drug elimination processes. Presystemic elimination and first pass effect. Dose-response relationship. Doses and dose-effect curves. Therapeutic index and safety margin. Mechanism of action of drugs. Structure-action relationship. Biological targets of drugs. Classification and structure of receptors. Quantitative aspects of drug-receptor interaction. Factors influencing the response to drugs. Adverse drug reactions.
Prof. Feletti Fausto: 1. Pharmacokinetics and sport 2. Effect of physical exercise on pharmacokinetics 3. Sympathetic system and hormonal axes 4. Exercise and the sympathetic system 5. Effect of physical exercise on the hypothalamus-pituitary-soma axis 6. Amino acids and hypothalamus-pituitary-soma axis 7. Effects of GH abuse 8. Hypothalamic-pituitary-thyroid axis: general information 9. Exercise and thyroid function 10. Hypothalamic-pituitary-gonadal axis: general information 11. Gonadotropins 12. Action of gonadotropins in males 13. Action of gonadotropins in females 14. Metabolic effects of testosterone 15. Metabolic effects of estrogen 16. Pharmacological and toxicological actions of anabolic steroids 17. Hypothalamic-pituitary-adrenal axis: general information 18. Exercise, stress and overtraining 19. Glucocorticoids and exercise 20. Mineralocorticoids and exercise 21. Sweating and management of the hydro-saline balance 22. Exercise and inflammation 23. Cortisones and NSAIDs 24. Emodoping - Doping - Anti-doping laws
Course Language
Italian
More information
The lecturers will provide presentations in pdf format or in another format and other material of study of the topics discussed.