Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe
Articolo
Data di Pubblicazione:
2013
Abstract:
HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
antiretroviral therapy; drug resistance; epidemiology; genotyping; HIV-1; Adult; CD4 Lymphocyte Count; Databases, Factual; Europe; Evolution, Molecular; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Multivariate Analysis; Mutation; Odds Ratio; Prevalence; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Sexual Behavior; pol Gene Products, Human Immunodeficiency Virus; Drug Resistance, Multiple, Viral; Infectious Diseases; Immunology and Allergy
Elenco autori:
Giacometti, A; Butini, L; Del Gobbo, R; Menzo, S; Tacconi, D; Corbelli, G; Zanussi, S; Monno, L; Punzi, G; Maggiolo, F; Callegaro, A; Calza, L; Pristerà, R; Turconi, P; Mandas, A; Tini, S; Zoncada, A; Paolini, E; Amadio, G; Sighinolfi, L; Zuccati, G; Morfini, M; Manetti, R; Corsi, P; Galli, L; Di Pietro, M; Bartalesi, F; Colao, G; Tosti, A; Di Biagio, A; Setti, M; Bruzzone, B; Penco, G; Trezzi, M; Orani, A; Pardelli, R; De Gennaro, M; Chiodera, A; Scalzini, A; Palvarini, L; Almi, P; Todaro, G; Monforte, Ad; Cicconi, P; Rusconi, S; Gismondo, M. R.; Gismondo, M. R.; Micheli, V; Biondi, M. L.; Gianotti, N; Capetti, A; Meraviglia, P; Boeri, E; Mussini, C; Pecorari, M; Soria, A; Vecchi, L; Santirocchi, M; Brustia, D; Ravanini, P; Dal Bello, F; Romano, N; Mancuso, S; Calzetti, C; Maserati, R; Filice, G; Baldanti, Fausto; Francisci, D; Parruti, G; Polilli, E; Sacchini, D; Martinelli, C; Consolini, R; Vatteroni, L; Vivarelli, A; Dionisio, D; Nerli, A; Lenzi, L; Magnani, G; Ortolani, P; Andreoni, M; Palamara, G; Fimiani, C; Palmisano, L; De Luca, A; Fadda, G; Vullo, V; Turriziani, O; Montano, M; Cenderello, G; Gonnelli, A; Zazzi, M; Palumbo, M; Ghisetti, V; Bonora, S; Delle Foglie, P; Rossi, C; Grossi, P; Seminari, E; Poletti, F; Mondino, V; Malena, M; Lattuada, E; Lengauer, T; Thielen, A; Däumer, M; Hoffmann, D; Kaiser, R; Schülter, E; Müller, C; Oette, M; Reuter, S; Esser, S; Fätkenheuer, G; Rockstroh, J; van de Vijver, Da; Incardona, F; Rosen Zvi, M; Lengauer, T; Camacho, R; Clotet, B; Ruiz i., Garcia B; Vilasarau i., Salat J; Font de Rubinat, I; Plasència i., Taradach A; Casabona i., Barbara J; Arguelagués i., Vidal E; Juárez, Rb; Gómez i., Clarés M; Gatnau, Jl; Planas i., Herrera E; Gelabert, Lr; Melia, Sm; Virosque, Mc; Arqué i., Ferrer Mt; Veiga i., Lluch A; Thalme, A; Svedhem, V; Bratt, G; Gargiulo, F; Manca, N; Paraninfo, G; Quiros Roldan, E; Castelnuovo, F; Vandamme, Am; Van Laethem, K; Van Wijngaerden, E; Ainsworth, J; Anderson, J; Babiker, A; Chadwick, D; Delpech, V; Dunn, D; Fisher, M; Gazzard, B; Gilson, R; Gompels, M; Hay, P; Hill, T; Johnson, M; Kegg, S; Leen, C; Nelson, M; Orkin, C; Palfreeman, A; Phillips, A; Pillay, D; Post, F; Sabin, C; Sachikonye, M; Schwenk, A; Walsh, J; Hill, T; Huntington, S; Josie, S; Phillips, A; Sabin, C; Thornton, A; Dunn, D; Glabay, A; Orkin, C; Lynch, J; Hand, J; Fisher, M; Perry, N; Tilbury, S; Churchill, D; Gazzard, B; Nelson, M; Waxman, M; Asboe, D; Mandalia, S; Delpech, V; Anderson, J; Munshi, S; Awosika, D; Post, F; Korat, H; Taylor, C; Gleisner, Z; Ibrahim, F; Campbell, L; Gilson, R; Brima, N; Williams, I; Schwenk, A; Ainsworth, J; Wood, C; Miller, S; Johnson, M; Youle, M; Lampe, F; Smith, C; Grabowska, H; Chaloner, C; Puradiredja, D; Walsh, J; Mackie, N; Winston, A; Weber, J; Ramzan, F; Leen, C; Wilson, A; Gompels, M; Allan, S; Palfreeman, A; Moore, A; Fox, L; Chadwick, D; Baillie, K; Kegg, S; Main, P; Allan, S; Hay, P; Dhillon, M; Martin, F; Douglas, S; Anderson, J; Asboe, D; Pozniak, A; Cameron, S; Chadwick, D; Churchill, D; Clark, D; Collins, S; Walker, C; Delpech, V; Pillay, D; Lazarus, L; Dunn, D; Dolling, D; Fearnhill, E; Castro, H; Porter, K; Coughlin, K; Dolling, D; Zuckerman, M; Geretti, Am; Booth, C; Goldberg, D; Gompels, M; Hale, A; Kaye, S; Kellam, P; Leigh Brown, A; Mackie, N; Orkin, C; Pillay, D; Phillips, A; Sabin, C; Smit, E; Templeton, K; Tilston, P; Tong, W; Thomas, S; Williams, I; Zhang, H; Zhang, H; Clark, D; Ushiro Lumb, I; Oliver, T; Bibby, D; Mitchell, S; Smit, E; Mbisa, T; Wildfire, A; Tandy, R; Shepherd, J; Chadwick, D; Maclean, A; Tong, W; Bennett, D; Hopkins, M; Tilston, P; Booth, C; Garcia Diaz, A; Kaye, S; Kirk, S; Sloot, P. M.
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