Enantioselective Mukaiyama-Michael reactions of 2-carbomethoxy cyclopentenone catalyzed by chiral bis(oxazoline)-Cu(II) complexes
Articolo
Data di Pubblicazione:
1996
Abstract:
The conjugate addition of propionate silylketene acetal 1 to
2-carbomethoxy cyclopentenone is promoted by bis(oxazoline)-Cu(II)
complexes with high diastereoselectivity and good enantiomeric excesses.
The absolute configuration of the product can be controlled by varying
the copper counterion. A catalytic version of the reaction was
developed, which gave ketoacid 5a in 72\% d.e. and 63\% e.e. Copyright
(C) 1996 Elsevier Science Ltd
2-carbomethoxy cyclopentenone is promoted by bis(oxazoline)-Cu(II)
complexes with high diastereoselectivity and good enantiomeric excesses.
The absolute configuration of the product can be controlled by varying
the copper counterion. A catalytic version of the reaction was
developed, which gave ketoacid 5a in 72\% d.e. and 63\% e.e. Copyright
(C) 1996 Elsevier Science Ltd
Tipologia CRIS:
1.1 Articolo in rivista
Elenco autori:
Bernardi, A; Colombo, G; Scolastico, C
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