Data di Pubblicazione:
2015
Abstract:
Preclinical data indicate there is strong synergism of action against Ewing sarcoma in sequential treatment with trabectedin followed by irinotecan and it appears to be related to a selective blockade of the transcription factor EWS-FLI1. This combination was evaluated in Ewing sarcoma patient who was progressing with standard therapies.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Adult; Camptothecin; Dioxoles; Humans; Male; Oncogene Proteins, Fusion; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Sarcoma, Ewing; Tetrahydroisoquinolines
Elenco autori:
Tancredi, R; Zambelli, A; Daprada, G A; Fregoni, V; Pavesi, L; Riccardi, A; Burdach, S; Grohar, P J; D'Incalci, M
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