Comparative studies on the neuro- and reproductive toxicity of acrylamide and its epoxide metabolite glycidamide in the rat.

The results of this study suggest that acrylamide may be effective per se in causing peripheral nervous system damage in rats after repeated exposure to toxic doses (25-50 mg/gkg/day) whereas other toxic effects of this agent, such as reproductive toxicity appear to be mediated by the metabolite glycidamide.