Data di Pubblicazione:
2006
Abstract:
The aim of the present study was to assess age-dependent changes of proteins in the vastus lateralis
muscle of physically active elderly and young subjects by a combination of two-dimensional difference
gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included
down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher
proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic
capacity.
muscle of physically active elderly and young subjects by a combination of two-dimensional difference
gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included
down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher
proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic
capacity.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
PROTEOME; SKELETAL MUSCLE; PLASTICITY
Elenco autori:
Gelfi, C; Vigano, A; Ripamonti, M; Pontoglio, A; Begum, S; Pellegrino, MARIA ANTONIETTA; Grassi, B; Bottinelli, Roberto; Wait, R; Cerretelli, P.
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