Sodium influx plays a major role in the membrane depolarization induced by oxygen and glucose deprivation in rat striatal spiny neurons
Articolo
Data di Pubblicazione:
1999
Abstract:
Striatal spiny neurons are selectively vulnerable to ischemia, but the ionic mechanisms underlying this selective vulnerability are unclear. Although a possible involvement of sodium and calcium ions has been postulated in the ischemia-induced damage of rat striatal neurons, the ischemia-induced ionic changes have never been analyzed in this neuronal subtype.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Glyburide; Calcium Channels; Rats; Wistar; Sodium Channels; Cerebral Cortex; Organ Culture Techniques; Hypoglycemic Agents; Magnesium; Potassium Channels; Glucose; Corpus Striatum; Calcium Channel Blockers; Sodium Channel Blockers; Potassium Channel Blockers; Egtazic Acid; Chelating Agents; Adenosine Triphosphate; Rats; Brain Ischemia; Animals; Calcium; Sodium; Patch-Clamp Techniques; Receptors; Glutamate; Membrane Potentials; Tetrodotoxin; Oxygen; Neurons; Tolbutamide
Elenco autori:
Calabresi, Paolo; Marfia, GIROLAMA ALESSANDRA; Centonze, Diego; Pisani, Antonio; Bernardi, Giorgio
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