Efficacy of propafenone in paramyotonia congenita

We studied a 42-year-old man belonging to a large family with several affected members including his two sons. He had received mexiletine, 200 mg three times daily. Clinical symptoms were measured by the Muscular Disability Rating Scale, before and after 1-month treatment with PH. Electrophysiologic investigations were also performed before and after treatment. After PH treatment, the patient reported complete relief from symptoms, without adverse effects.