Data di Pubblicazione:
2021
Abstract:
High-grade gliomas (HGGs) still have a high rate of recurrence and lethality. Gene therapies were projected to overcome the therapeutic resilience of HGGs, due to the intrinsic genetic heterogenicity and immune evasion pathways. The present literature review strives to provide an updated overview of the novel gene therapies for HGGs treatment, highlighting evidence from clinical trials, molecular mechanisms, and future perspectives.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
gene therapy; glioblastoma; immunomodulation; malignant brain tumor; oncolytic viruses; suicide genes; target gene; tumor suppressor genes
Elenco autori:
Giotta Lucifero, Alice; Luzzi, Sabino
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