Data di Pubblicazione:
2022
Abstract:
We propose a diffuse interface model to describe a tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a mechanical equilibrium equation with phase-dependent elasticity coefficients. The resulting PDE system couples two Cahn???Hilliard type equations for the tumor phase and the healthy phase with a PDE linking the evolution of the interstitial fluid to the pressure of the system, a reaction-diffusion type equation for the nutrient proportion, and a quasistatic momentum balance. We prove here that the corresponding initial-boundary value problem has a solution in appropriate function spaces.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
porous medium; diffuse interface model; Cahn-Hilliard equation; reaction-diffusion equation; Tumor model
Elenco autori:
Krejci, P; Rocca, E; Sprekels, J
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