Data di Pubblicazione:
2022
Abstract:
PTEN gene mutations are frequently found in the genetic landscape of high-grade gliomas since they influence cell proliferation, proangiogenetic pathways, and antitumoral immune response. The present bioinformatics analysis explores the PTEN gene expression profile in HGGs as a prognostic factor for survival, especially focusing on the related immune microenvironment. The effects of PTEN mutation on the susceptibility to conventional chemotherapy were also investigated.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
PTEN; The Cancer Genome Atlas; glioblastoma; high-grade gliomas; phosphatase and tensin homolog; temozolomide
Elenco autori:
Giotta Lucifero, Alice; Luzzi, Sabino
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