Electrochemical Behavior and Voltammetric Determination of Two Synthetic Aroyl Amides Opioids

In the present work, we describe the electrochemical behaviour of two opioids structurally related to aroyl amides of forensic interest, namely U-47700 and AH-7921. The data obtained allowed for the mise-au-point of a voltammetric determination protocol, that relies on differential pulse voltammetry (DPV) at a glassy carbon electrode in ethanol/0.1 M lithium perchlorate/0.10 M 2,6-lutidine. To apply the method to the analysis of real samples (urines), a clean-up and a preconcentration strategy by solid phase extraction (SPE) using the adsorbent Florisil have been developed. LOQ of 0.2 mu g center dot mL(-1) in urine samples with an enrichment factor of 20 and linear range from 5 to 150 mu g center dot mL(-1) were obtained.