Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C.
Articolo
Data di Pubblicazione:
2011
Abstract:
Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Adult; Aged; 80 and over; CD4 Lymphocyte Count; Case-Control Studies; Female; Genotype; HIV Infections; complications/diagnosis/genetics; Hepacivirus; genetics; Hepatitis C; genetics/virology; Humans; Interleukins; Male; Middle Aged; Polymorphism; Single Nucleotide; RNA; Viral; analysis; Regression Analysis; Treatment Outcome
Elenco autori:
Jacob, Nattermann; Martin, Vogel; Hans Dieter, Nischalke; Mark, Danta; Stefan, Mauss; Hans Jörg, Stellbrink; Axel, Baumgarten; Christoph, Mayr; Bruno, Raffaele; Cristina, Tural; Gerd, Klausen; Bonaventura, Clotet; Uwe, Naumann; Thomas, Lutz; Michael, Rausch; Knud, Schewe; Bernhard, Bienek; Georg, Haerter; Tilman, Sauerbruch; Juergen K., Rockstroh; Ulrich, Spengler
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