Analytical Determination and Electrochemical Characterization ofthe Oxazolidinone Antibiotic Linezolid
Articolo
Data di Pubblicazione:
2011
Abstract:
Linezolid belongs to a class of antibiotics known as oxazolidinones. It is receiving great attention due to its activity
toward multidrugs resistant bacteria, and simple and cheap methods for the analysis of this compound in pharmaceutical
preparations are required. In this work, the electrochemistry of the antibiotic linezolid was investigated and
a differential pulse voltammetric method based on the oxidation of the oxazolidinonic compound at a glassy carbon
electrode has been developed and optimized for its determination; LOD of 50 mgL1 and a linearity up to
200 mgL1 were reported. The electrochemical process was studied by using different electrochemical techniques
and confirmed by HPLC-MS/MS.
toward multidrugs resistant bacteria, and simple and cheap methods for the analysis of this compound in pharmaceutical
preparations are required. In this work, the electrochemistry of the antibiotic linezolid was investigated and
a differential pulse voltammetric method based on the oxidation of the oxazolidinonic compound at a glassy carbon
electrode has been developed and optimized for its determination; LOD of 50 mgL1 and a linearity up to
200 mgL1 were reported. The electrochemical process was studied by using different electrochemical techniques
and confirmed by HPLC-MS/MS.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Linezolid; Differential pulse voltammetry; Mechanistic electrochemistry
Elenco autori:
Merli, Daniele; Pretali, Luca; Fasani, Elisa; Albini, Angelo; Profumo, Antonella
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