Alveolar septal widening as an "alert" signal to look into lung antibody-mediated rejection: A multicenter pilot study

Antibody mediated rejection (AMR) plays an important role in allograft dysfunction. Acute lung injury (ALI), endotheliitis, capillary inflammation and C4d positivity have been described as morphological features conventionally associated with lung AMR. A multidisciplinary, international task force reviewed AMR cases in the context of four face-to-face meetings. Septal widening was a frequent, striking histological feature recognized firstly and easily at low-power magnification. This study aimed to evaluate whether septal widening could represent an "alert" signal for AMR.