Mechanism of resistance to an antitubercular 2-thiopyridine derivative that is also active against Burkholderia cenocepacia.

The discovery of new compounds able to inhibit Burkholderia cenocepacia growth is of primary importance for cystic fibrosis patients. Here the mechanism of resistance to a new pyridine-derivative, already shown to be effective against Mycobacterium tuberculosis, and showing a good activity toward B. cenocepacia, was investigated. An increased expression of an RND efflux system was detected in resistant mutants, thus confirming their important role in B. cenocepacia antibiotic resistance.