Data di Pubblicazione:
2010
Abstract:
BACKGROUND:
Whether pregnancy impacts on the long-term outcome of immunoglobulin A (IgA) nephropathy is unknown. This study aims to compare the long-term outcome of kidney disease in women with IgA nephropathy and preserved kidney function who did and did not become pregnant.
STUDY DESIGN:
Multicenter longitudinal cohort study.
SETTING & PARTICIPANTS:
Women of childbearing age with biopsy-proven IgA nephropathy, serum creatinine level
Pregnancy, treated as a time-dependent variable; baseline proteinuria; hypertension; and kidney biopsy histologic characteristics.
OUTCOME & MEASURES:
Rate of change in estimated creatinine clearance, change in proteinuria, and new-onset hypertension.
RESULTS:
245 patients were enrolled. Of these, 223 women (136 and 87 in the pregnancy and nonpregnancy groups, respectively) had serum creatinine levels
Unrecognized or unmeasured factors associated with the decision of becoming pregnant might have influenced results.
CONCLUSIONS:
Pregnancy does not seem to affect the long-term outcome of kidney disease in women with IgA nephropathy and preserved kidney function
Whether pregnancy impacts on the long-term outcome of immunoglobulin A (IgA) nephropathy is unknown. This study aims to compare the long-term outcome of kidney disease in women with IgA nephropathy and preserved kidney function who did and did not become pregnant.
STUDY DESIGN:
Multicenter longitudinal cohort study.
SETTING & PARTICIPANTS:
Women of childbearing age with biopsy-proven IgA nephropathy, serum creatinine level
Pregnancy, treated as a time-dependent variable; baseline proteinuria; hypertension; and kidney biopsy histologic characteristics.
OUTCOME & MEASURES:
Rate of change in estimated creatinine clearance, change in proteinuria, and new-onset hypertension.
RESULTS:
245 patients were enrolled. Of these, 223 women (136 and 87 in the pregnancy and nonpregnancy groups, respectively) had serum creatinine levels
Unrecognized or unmeasured factors associated with the decision of becoming pregnant might have influenced results.
CONCLUSIONS:
Pregnancy does not seem to affect the long-term outcome of kidney disease in women with IgA nephropathy and preserved kidney function
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Adult; Disease Progression; Pregnancy Pregnancy
Elenco autori:
Limardo, M; Pozzi, C; Imbasciati, E; Surian, M; Torres, D; Gregorini, G; Magistroni, R; Casellato, D; Gammaro, L; Beati, S; Ambroso, G; Maggio, M; Del Giudice, A; De Cristofaro, V; Gallo, E; Gernone, G; Marega, A; Rustichelli, R; Cabiddu, G; Rollino, C; Fanciulli, E; Feriozzi, S; Pecchini, P; Bizzarri, D; D'Amico, M; Proietti, E; Baratelli, L; Battista Reinero, G; Garibotto, G; Rocchietti, M; Allegri, L; Dugo, M; Cirami, L; Esposito, Ciro; Amico, L; Mariani, P; Baroli, A; Giannattasio, M; Stratta, P; Montanaro, D; Gesualdo, L; Daidone, G; Manfellotto, D; Castellino, S; Gregorini, Imbasciati
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