Data di Pubblicazione:
2015
Abstract:
Ten Iranian bentonites, sampled fromthe deposits of Chah-Golestan, Chah-Pirouz, Chah-Keshmir and Chah-Taleb
(Sarayan), Gholeh-Gelia and Kharman-Sar (Ferdows, Khorasan), Mehrejan (Khoor) and Manian (Zagros) were
analyzed to evaluate their potentialities as pharmaceutical products. The mineralogy, chemistry, pH, microbial
content, powder flowcharacteristics, swelling capacity, cation exchange capacity, specific surface area, sedimentation
volume, and rheological properties of all samples were determined. The bentonite located in carbonate
rocks (Zagros) is made up of calcium montmorillonite (97%) and quartz (3%). The rest of the bentonites are
hosted by Eocene volcanic rocks and aremainlymade up of sodiummontmorillonite (47%–84%) and cristobalite
(up to 39%), with lesser quantities of quartz, calcite, plagioclase, zeolites and halite. Two of the samples (those
located at Manian and Chah-Golestan C) showed appropriate composition, purity and technical properties to
be used in pharmaceutical applications, whereas the rest would require purification or improvement of their
properties. In particular, the samples could be used for topical dosage forms as rheological additives.
(Sarayan), Gholeh-Gelia and Kharman-Sar (Ferdows, Khorasan), Mehrejan (Khoor) and Manian (Zagros) were
analyzed to evaluate their potentialities as pharmaceutical products. The mineralogy, chemistry, pH, microbial
content, powder flowcharacteristics, swelling capacity, cation exchange capacity, specific surface area, sedimentation
volume, and rheological properties of all samples were determined. The bentonite located in carbonate
rocks (Zagros) is made up of calcium montmorillonite (97%) and quartz (3%). The rest of the bentonites are
hosted by Eocene volcanic rocks and aremainlymade up of sodiummontmorillonite (47%–84%) and cristobalite
(up to 39%), with lesser quantities of quartz, calcite, plagioclase, zeolites and halite. Two of the samples (those
located at Manian and Chah-Golestan C) showed appropriate composition, purity and technical properties to
be used in pharmaceutical applications, whereas the rest would require purification or improvement of their
properties. In particular, the samples could be used for topical dosage forms as rheological additives.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Iranian bentonites, Montmorillonite, Pharmaceutical formulations, Trace elements, Thixotropy, Excipient
Elenco autori:
Modabberi, Soroush; Namayandeh, Alireza; López Galindo, Alberto; Viseras, Cesar; Setti, Massimo; Ranjbaran, Mohsen
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