To provide advanced knowledge on the methodologies and approaches to design and optimize compounds for identifying drug candidates.
Course Prerequisites
Basic knowledge of organic chemistry, pharmacology and Medicinal Chemistry is required.
Teaching Methods
Teaching methods used in the course include lectures, problem-based learning groups, independent study. Discussion of the lecture topics during class is encouraged.
Assessment Methods
The exam includes an oral exam consisting of a discussion of a scientific article, to evaluate the depth of understanding in the topics of the program. It will be also evaluated the ability to speak with propriety of language and organization of the subject exposed.
Texts
The Practice of Medicinal Chemistry 4th Edition, Camille Wermuth David Aldous Pierre Raboisson Didier Rognan, ISBN: 9780124172050
Green Techniques for Organic Synthesis and Medicinal Chemistry, 2nd Edition, Wei Zhang (Editor), Berkeley W. Cue (Editor), Wiley, 2018, ISBN: 978-1-119-28816-9
Microwave Heating: Electromagnetic Fields Causing Thermal and Non-Thermal Effects, Edited by Gennadiy I. Churyumov, IntechOpen, 2021, ISBN: 978-1-83968-227-8, Print ISBN: 978-1-83968-226-1
Scientific articles
Contents
The course offers insights on specific topics that play a key role in the drug discovery process. Drug screening techniques for the drug discovery. Preparation of drug libraries (parallel and combinatorial synthesis, microwave-assisted organic synthesis, flow chemistry). Several scientific articles will be discussed particularly focussing on communication using a correct scientific terminology.
