ID:
501708
Durata (ore):
32
CFU:
4
SSD:
PATOLOGIA GENERALE
Anno:
2025
Dati Generali
Periodo di attività
Secondo Semestre (02/03/2026 - 29/05/2026)
Syllabus
Obiettivi Formativi
At the successful conclusion of this module, you should be able to demonstrate the following module level learning outcomes (MLOs):
MLO.1 Knowledge and Understanding
You will be provided a comprehensive view of immunity, including the evolutionary basis of self - non self discrimination, the main types of immunity (innate and adaptive) and of the molecular and cellular processes responsible for resistance to infection and immune surveillance. You will be able to describe key cells and molecules, and their roles in damage, inflammation, and repair, and the physiology and pathology of the immune system.
MLO.2 Application of Knowledge
You will be able to apply immune concepts to disease, interpret immune changes clinically, and perform related lab techniques (e.g., ELISA, cell assays).
MLO.3 Autonomy of Judgement
You will be able to make informed judgments about immune functions in disease and reflect on common immune mechanisms across conditions.
MLO.4 Communication Skills
You will be able to clearly communicate immune processes and present lab findings.
MLO.5 Learning Skills
You will be able to navigate lectures, practicals, and online tools, integrating immunology with pathology and physiology for clinical reasoning.
MLO.1 Knowledge and Understanding
You will be provided a comprehensive view of immunity, including the evolutionary basis of self - non self discrimination, the main types of immunity (innate and adaptive) and of the molecular and cellular processes responsible for resistance to infection and immune surveillance. You will be able to describe key cells and molecules, and their roles in damage, inflammation, and repair, and the physiology and pathology of the immune system.
MLO.2 Application of Knowledge
You will be able to apply immune concepts to disease, interpret immune changes clinically, and perform related lab techniques (e.g., ELISA, cell assays).
MLO.3 Autonomy of Judgement
You will be able to make informed judgments about immune functions in disease and reflect on common immune mechanisms across conditions.
MLO.4 Communication Skills
You will be able to clearly communicate immune processes and present lab findings.
MLO.5 Learning Skills
You will be able to navigate lectures, practicals, and online tools, integrating immunology with pathology and physiology for clinical reasoning.
Prerequisiti
The prerequisites are indicated in the Integrated Course Syllabus for BOD
Metodi didattici
Teaching methods include lectures, discussion and guided independent study. Lectures present key concepts (supports CLO.1, CLO.2) and include interactive discussion of clinical cases (supports CLO.2-3), guided readings and the e-learning platform (supports CLO.5). Teaching will include guidance to help you prepare for the exam (supports CLO.4) and throughout you will be presented with references to further readings and other materials to support your development, including exercises (supports CLO.5).
Verifica Apprendimento
The assessment process is indicated in the Integrated Course Syllabus for BOD.
Testi
The examination paper is based on the content of the module(s) as taught.
For the purposes of revision and exam preparation, however, there is a wide range of excellent textbooks for Natural Science and Medical students and suggested texts are provided below.
Suggested texts:
Delves PJ, Martin SJ, Burton DR, Roitt IM. Roitt's Essential Immunology. 13th ed. Wiley Blackwell; 2017.
Wood P. Understanding Immunology. 3rd ed. Prentice Hall; 2011.
Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 10th ed. Elsevier Saunders; 2021.
Murphy K, Weaver C. Janeway's Immunobiology. 10th ed. Garland Science; 2016.
Owen JA, Punt J, Stranford SA. Kuby's Immunology. 8th ed. W.H. Freeman and Company; 2018.
Male D, Brostoff J, Roth DB, Roitt I. Immunology. 8th ed. Saunders Elsevier; 2012.
Additional materials, including selected scientific articles will be distributed via the KIRO e-learning platform
For the purposes of revision and exam preparation, however, there is a wide range of excellent textbooks for Natural Science and Medical students and suggested texts are provided below.
Suggested texts:
Delves PJ, Martin SJ, Burton DR, Roitt IM. Roitt's Essential Immunology. 13th ed. Wiley Blackwell; 2017.
Wood P. Understanding Immunology. 3rd ed. Prentice Hall; 2011.
Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 10th ed. Elsevier Saunders; 2021.
Murphy K, Weaver C. Janeway's Immunobiology. 10th ed. Garland Science; 2016.
Owen JA, Punt J, Stranford SA. Kuby's Immunology. 8th ed. W.H. Freeman and Company; 2018.
Male D, Brostoff J, Roth DB, Roitt I. Immunology. 8th ed. Saunders Elsevier; 2012.
Additional materials, including selected scientific articles will be distributed via the KIRO e-learning platform
Contenuti
The Immunology module explores the biological mechanisms of disease resistance, providing you with both evolutionary and molecular perspectives on immunity.
Topics you will study in this module include:
Introduction to Immunity
– Artificial and natural immunity, vaccination history, public health impact, McKeown’s thesis, and vaccine controversies.
Foundations of Immunology
– Soluble immunity (complement, antibodies), cellular immunity (phagocytosis, graft rejection, transplantation).
Evolution of Immunity
– Innate vs. adaptive immunity; immunity in bacteria, invertebrates, and early chordates; symbiosis and immune function.
Innate Immunity
– Immune cells, inflammation, coagulation, nucleic acid sensing, interferon and NF-kB pathways, recognition of altered self.
Adaptive Immunity
– Lymphocytes, lymphoid tissues, B and T cell roles, antigen receptors (BCR, TCR), MHC molecules, and immune coordination.
Antigens and Presentation
– Antigen properties, epitopes, adjuvants, superantigens, MHC class I & II structure and function.
Antibodies and TCRs
– Structure and function of antibodies and TCRs, monoclonal antibody production, chimeric/humanized antibodies, phage display.
Genetics of Immune Receptors
– Antibody and TCR loci, gene rearrangement, V(D)J recombination, repertoire diversity, and the RAG1/2 complex.
Antibody Maturation
– Primary vs. secondary responses, somatic hypermutation, repertoire shifts.
Lymphocyte Development
– B and T cell maturation, allelic exclusion, isotype switching, self-tolerance, regulatory subpopulations.
Cytokine Networks
– Structure and function of cytokines and their receptors; redundancy and pleiotropy in signaling.
Effector Responses
– CTL and NK cell cytotoxicity, ADCC, delayed-type hypersensitivity (DTH).
Complement System
– Classical, lectin, and alternative pathways, membrane attack complex, regulation, bacterial evasion, and evolution.
Vaccines and Immunity to Infection
– Live, inactivated, subunit, toxoid, DNA/RNA vaccines.
Immunodeficiencies
– Primary and acquired immune deficiencies.
Hypersensitivity and Autoimmunity
– Types I–IV hypersensitivity, autoimmune mechanisms, classification, and tolerance breakdown.
Topics you will study in this module include:
Introduction to Immunity
– Artificial and natural immunity, vaccination history, public health impact, McKeown’s thesis, and vaccine controversies.
Foundations of Immunology
– Soluble immunity (complement, antibodies), cellular immunity (phagocytosis, graft rejection, transplantation).
Evolution of Immunity
– Innate vs. adaptive immunity; immunity in bacteria, invertebrates, and early chordates; symbiosis and immune function.
Innate Immunity
– Immune cells, inflammation, coagulation, nucleic acid sensing, interferon and NF-kB pathways, recognition of altered self.
Adaptive Immunity
– Lymphocytes, lymphoid tissues, B and T cell roles, antigen receptors (BCR, TCR), MHC molecules, and immune coordination.
Antigens and Presentation
– Antigen properties, epitopes, adjuvants, superantigens, MHC class I & II structure and function.
Antibodies and TCRs
– Structure and function of antibodies and TCRs, monoclonal antibody production, chimeric/humanized antibodies, phage display.
Genetics of Immune Receptors
– Antibody and TCR loci, gene rearrangement, V(D)J recombination, repertoire diversity, and the RAG1/2 complex.
Antibody Maturation
– Primary vs. secondary responses, somatic hypermutation, repertoire shifts.
Lymphocyte Development
– B and T cell maturation, allelic exclusion, isotype switching, self-tolerance, regulatory subpopulations.
Cytokine Networks
– Structure and function of cytokines and their receptors; redundancy and pleiotropy in signaling.
Effector Responses
– CTL and NK cell cytotoxicity, ADCC, delayed-type hypersensitivity (DTH).
Complement System
– Classical, lectin, and alternative pathways, membrane attack complex, regulation, bacterial evasion, and evolution.
Vaccines and Immunity to Infection
– Live, inactivated, subunit, toxoid, DNA/RNA vaccines.
Immunodeficiencies
– Primary and acquired immune deficiencies.
Hypersensitivity and Autoimmunity
– Types I–IV hypersensitivity, autoimmune mechanisms, classification, and tolerance breakdown.
Lingua Insegnamento
INGLESE
Altre informazioni
With reference to the new regulations for the inclusion of students with special needs, the teacher will provide the assistance and teaching
material necessary for the students' training to prepare for the exam.
material necessary for the students' training to prepare for the exam.
Corsi
Corsi
MEDICINE AND SURGERY
Laurea Magistrale Ciclo Unico 6 Anni
6 anni
No Results Found
Persone
Persone
No Results Found