ID:
506521
Durata (ore):
16
CFU:
2
SSD:
FARMACOLOGIA
Anno:
2026
Dati Generali
Periodo di attività
Primo Semestre (01/10/2026 - 15/01/2027)
Syllabus
Obiettivi Formativi
Knowledge and Understanding
1. Describe the general principles of pharmacology, including drug administration, absorption, distribution, metabolism, elimination, and factors influencing drug response.
2. Explain the molecular mechanisms underlying drug action, including drug–receptor interactions, receptor classification, affinity, efficacy, and antagonism.
Applying Knowledge and Understanding
3. Apply pharmacological principles to interpret quantitative aspects of drug action, including receptor occupancy, dose–response relationships, and factors affecting therapeutic and toxic effects.
1. Describe the general principles of pharmacology, including drug administration, absorption, distribution, metabolism, elimination, and factors influencing drug response.
2. Explain the molecular mechanisms underlying drug action, including drug–receptor interactions, receptor classification, affinity, efficacy, and antagonism.
Applying Knowledge and Understanding
3. Apply pharmacological principles to interpret quantitative aspects of drug action, including receptor occupancy, dose–response relationships, and factors affecting therapeutic and toxic effects.
Prerequisiti
Please refer to the Integrated Course Syllabus for [506520] - DRUG DISCOVERY AND ACTIONS
Metodi didattici
The module introduces the fundamental principles of pharmacology, with particular emphasis on the molecular mechanisms of drug action and the quantitative aspects of drug–receptor interactions. Students will examine how drugs reach their site of action, interact with biological targets, and produce therapeutic or adverse effects.
Topics include:
Principles of drug disposition
• Routes of drug administration
• Drug movement across biological membranes
• Passive diffusion, transporters, and endocytosis
• Factors influencing drug absorption and distribution
• Basic principles of drug metabolism and elimination
• Introduction to pharmacokinetic parameters
Pharmacodynamics and mechanisms of drug action
• Principles of drug targets and receptor theory
• Classification and characteristics of receptors
• Drug–receptor interactions
• Affinity, fractional receptor occupancy, and efficacy
• Dose–response relationships
• Agonists and antagonists
• Competitive and non-competitive antagonism
• Orthosteric and allosteric modulation of receptors
• Examples of clinically relevant receptor systems
Teaching methods include formal lectures, interactive discussions, and guided independent study.
Lectures provide the fundamental knowledge required to understand the principles of drug disposition, pharmacokinetics, pharmacodynamics, and molecular mechanisms of drug action, including drug–receptor interactions and quantitative aspects of pharmacological responses (supports LO1–LO2). Interactive discussions and problem-solving activities support the application of pharmacological concepts to the interpretation of dose–response relationships, receptor interactions, and factors influencing drug efficacy and toxicity (supports LO3).
Guided independent study, recommended readings, and additional learning resources support consolidation of knowledge and preparation for the integrated written examination (supports LO1–LO3).
Topics include:
Principles of drug disposition
• Routes of drug administration
• Drug movement across biological membranes
• Passive diffusion, transporters, and endocytosis
• Factors influencing drug absorption and distribution
• Basic principles of drug metabolism and elimination
• Introduction to pharmacokinetic parameters
Pharmacodynamics and mechanisms of drug action
• Principles of drug targets and receptor theory
• Classification and characteristics of receptors
• Drug–receptor interactions
• Affinity, fractional receptor occupancy, and efficacy
• Dose–response relationships
• Agonists and antagonists
• Competitive and non-competitive antagonism
• Orthosteric and allosteric modulation of receptors
• Examples of clinically relevant receptor systems
Teaching methods include formal lectures, interactive discussions, and guided independent study.
Lectures provide the fundamental knowledge required to understand the principles of drug disposition, pharmacokinetics, pharmacodynamics, and molecular mechanisms of drug action, including drug–receptor interactions and quantitative aspects of pharmacological responses (supports LO1–LO2). Interactive discussions and problem-solving activities support the application of pharmacological concepts to the interpretation of dose–response relationships, receptor interactions, and factors influencing drug efficacy and toxicity (supports LO3).
Guided independent study, recommended readings, and additional learning resources support consolidation of knowledge and preparation for the integrated written examination (supports LO1–LO3).
Verifica Apprendimento
Please refer to the Integrated Course Syllabus for [506520] - DRUG DISCOVERY AND ACTIONS
Testi
Recommended texts include:
Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 12th ed. McGraw-Hill; 2011.
Harvey RA, Clark MA, Finkel R, Rey JA, Whalen K. Lippincott's Illustrated Reviews: Pharmacology. 5th ed. Lippincott Williams & Wilkins; 2011.
Katzung BG, Masters SB, Trevor AJ. Basic & Clinical Pharmacology. 12th ed. McGraw-Hill Medical; 2012.
Waller DG, Renwick AG, Hillier K. Medical Pharmacology and Therapeutics. 3rd ed. W.B. Saunders; 2009.
Additional materials will be distributed via the KIRO e-learning platform
Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 12th ed. McGraw-Hill; 2011.
Harvey RA, Clark MA, Finkel R, Rey JA, Whalen K. Lippincott's Illustrated Reviews: Pharmacology. 5th ed. Lippincott Williams & Wilkins; 2011.
Katzung BG, Masters SB, Trevor AJ. Basic & Clinical Pharmacology. 12th ed. McGraw-Hill Medical; 2012.
Waller DG, Renwick AG, Hillier K. Medical Pharmacology and Therapeutics. 3rd ed. W.B. Saunders; 2009.
Additional materials will be distributed via the KIRO e-learning platform
Contenuti
The module introduces the fundamental principles of pharmacology, with particular emphasis on the molecular mechanisms of drug action and the quantitative aspects of drug–receptor interactions. Students will examine how drugs reach their site of action, interact with biological targets, and produce therapeutic or adverse effects.
Topics include:
Principles of drug disposition
• Routes of drug administration
• Drug movement across biological membranes
• Passive diffusion, transporters, and endocytosis
• Factors influencing drug absorption and distribution
• Basic principles of drug metabolism and elimination
• Introduction to pharmacokinetic parameters
Pharmacodynamics and mechanisms of drug action
• Principles of drug targets and receptor theory
• Classification and characteristics of receptors
• Drug–receptor interactions
• Affinity, fractional receptor occupancy, and efficacy
• Dose–response relationships
• Agonists and antagonists
• Competitive and non-competitive antagonism
• Orthosteric and allosteric modulation of receptors
• Examples of clinically relevant receptor systems
Topics include:
Principles of drug disposition
• Routes of drug administration
• Drug movement across biological membranes
• Passive diffusion, transporters, and endocytosis
• Factors influencing drug absorption and distribution
• Basic principles of drug metabolism and elimination
• Introduction to pharmacokinetic parameters
Pharmacodynamics and mechanisms of drug action
• Principles of drug targets and receptor theory
• Classification and characteristics of receptors
• Drug–receptor interactions
• Affinity, fractional receptor occupancy, and efficacy
• Dose–response relationships
• Agonists and antagonists
• Competitive and non-competitive antagonism
• Orthosteric and allosteric modulation of receptors
• Examples of clinically relevant receptor systems
Lingua Insegnamento
INGLESE
Altre informazioni
Please refer to the Integrated Course Syllabus for [506520] - DRUG DISCOVERY AND ACTIONS
Corsi
Corsi
MEDICINE AND SURGERY
Laurea Magistrale Ciclo Unico 6 Anni
6 anni
No Results Found
Persone
Persone
No Results Found