The course of Applied Biology aims to provide basic knowledge of Human Biology and updated knowledge on the most recent discoveries and its applications in clinical practice.
Teaching Methods
Frontal lessons
Assessment Methods
Written test/ Oral test
Texts
Biologia e Genetica Campbell and Reece Pearson o Biologia Cellulare/ Genetica e biologia molecolare Autore: raven - johnson - mason - losos - singer PICCIN
pdf and notes from lessons
Contents
Program The eukaryotic cell: chemical constitution, differential expression. The plasmatic membrane. Passive and active transport. Examples of canalopathies: Long QT syndrome, familial hemiplegic migraine and cystic fibrosis Mutations: gene, genomic and chromosomal mutations and related examples Chromosomal abnormalities. Indications for chromosome/genetic analysis Examples of numerical and structural chromosomal anomalies. Microdeletion syndromes. Molecular cytogenetic techniques. Fluorescent in situ hybridization, array-based comparative genomic hybridization and Next Generation Sequencing. Mutation analysis techniques. Mendelian inheritance: dominant and recessive autosomal diseases. Interpretation of genealogical trees. Acondroplasic dwarfism, imperfect osteogenesis, Marfan Syndrome. Cystic fibrosis as example of autosomal recessive disease. The cell cycle. Mitosis and Meiosis. Meiotic non- disjunction. Cancer: Oncogenes and Oncosuppressors. Li-Fraumeni syndrome and Ataxia-Telangectasia.
